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EPAC2 Antibody

Product no.: EPAC-201AP

$320.00

General Information
Product	Epac2 Antibody
Description	Affinity Purified Rap Guanine Nucleotide Exchange Factor 3 Antibody
Verified Applications	CM, ELISA, ICC/IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rabbit, Rat
Immunogen	Synthetic peptide corresponding to amino acids 743-762 of Epac2 protein. Sequence: CPREQFDSLTPLPEQEGPT
Specificity	This antibody does not cross react with other Epac family proteins.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.67 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500. Predicted molecular weight: 112 kDa
Protein
Uniprot #	Q9Z1C7
Overview	Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
Molecular Function	Guanine-nucleotide releasing factor
Subcellular Location	Cytoplasm; Membrane; Peripheral membrane protein
Structure	Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A.
Alternative Nomenclature	CAMP GEFII antibody cAMP regulated guanine nucleotide exchange factor II antibody CGEF2 antibody Epac 2 antibody Exchange protein directly activated by cAMP 2 antibody Nbla00496 antibody Putative protein product of Nbla00496 antibody Rap guanine nucleotide exchange factor (GEF) 4 antibody RAPGEF 4 antibody

Protein information supplied by UniProt

Fabgennix Epac2 Antibody has been used in 1 Publication

McPartlin, L.A., P.E. Visconti, and S.J. Bedford-Guaus. “Guanine-Nucleotide Exchange Factors (RAPGEF3/RAPGEF4) Induce Sperm Membrane Depolarization and Acrosomal Exocytosis in Capacitated Stallion Sperm.”Biology of Reproduction 85.1 (2011): 179–188. PMC3123385

Confocal Microscopy, Immunofluorescence, Western Blot; Horse, Mouse

Publishing research using EPAC-201AP? Please let us know, we can cite the reference in this datasheet.

Customer ratings for EPAC2 Antibody

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Average rating: 4

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from Verified Customer on 01/04/2021

Western blot. Rabbit cell lysate- whole cell (pancreatic acini). 20µg rabbit pancreatic acini loaded on reduced denaturing (7.5%) gel. 5% BSA as blocking agent for 2 hours at 25°C.

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Price

EPAC2 Antibody FITC

EPAC2-FITC

$375.00 *

EPAC2 Antibody BIOTIN

EPAC2-BIOTIN

$375.00 *

EPAC2 Blocking Peptide

P-EPAC2

$155.00 *

EPAC2 Positive Control

PC-EPAC2

$200.00 *

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EPAC-101AP

EPAC1 Antibody

$320.00 *

EPAC-112AP

EPAC1 Antibody

$320.00 *

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Browse these categories as well: cAMP, Guanylate Cyclases & GTPases, cGMP, Primaries

PDE6C / PDE6 Delta Antibody

Product no.: PDE6C-101AP

$285.00

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Description
Publications

General Information
Product	PDE6 delta / PDE6C Cone Specific Antibody
Description	Affinity Purified cone cGMP phosphodiesterase Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Bovine, Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 1-75 on cone-specific PDE6C protein.
Accession #	GenBank: CAA64079.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.50-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:50-1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P51160
Overview	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Molecular Function	Hydrolase, 3',5'-cyclic-GMP phosphodiesterase activity, cGMP binding
Subcellular Location	Cell membrane; Lipid-anchor; Cytoplasmic side
Structure	Composed of two alpha' subunits that are associated with 3 smaller proteins of 11, 13, and 15 kDa.
Alternative Nomenclature	cGMP phosphodiesterase 6C antibody COD4 antibody PDE 6C antibody PDE6 alpha prime antibody PDEA2 antibody Phosphodiesterase 6C cGMP specific cone alpha prime antibody

Protein information supplied by UniProt

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PDE6C Antibody FITC

PDE6C-FITC

$375.00 *

PDE6C Antibody BIOTIN

PDE6C-BIOTIN

$375.00 *

PDE6C Blocking Peptide

P-PDE6C

$155.00 *

PDE6C Positive Control

PC-PDE6C

$200.00 *

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PD6A-101AP

PDE6 Alpha Antibody

$320.00 *

PD6-201AP

PDE6 Beta Antibody

$320.00 *

PD6-301AP

PDE6 Gamma Antibody

$320.00 *

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Browse these categories as well: cGMP, cAMP, Vision, Primaries, Phosphodiesterases, Vision & Olfaction

PDE10A Antibody

Product no.: PD10A-101AP

$320.00

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General Information
Product	PDE10A Antibody
Description	Affinity Purified Phosphodiesterase 10A
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat
Immunogen	Synthetic peptide (Human) taken against a common sequence near the 250-325 amino acids downstream of N-terminal region of PDE10A. Synthetic MAP.
Specificity	This antibody has no cross-reactivity against any other PDE family members tested so far. This antibody will detect all PDE10A variants and subtypes.
Accession #	GenBank: AAD32596.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.7 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:100-1:150
Dot Blot	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:100-1:150
Immunofluorescence	1:100-1:150
Immunohistochemistry	1:100-1:150
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q9Y233
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Molecular Function	Hydrolase, metal-ion binding, cGMP binding
Subcellular Location	Cytoplasm
Expression	Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Structure	Homodimer
Alternative Nomenclature	5''-cyclic phosphodiesterase 10A antibody cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A antibody FLJ11894 antibody HSPDE10A antibody Phosphodiesterase 10A antibody

Protein information supplied by UniProt

Fabgennix PDE10A Antibody has been used in 14 Publications
D'Angelo, Vincenza, et al. "Phosphodiesterase-10A inverse changes in striatopallidal and striatoentopeduncular pathways of a transgenic mouse model of DYT1 dystonia." Journal of Neuroscience 37.8 (2017) PMID28115486	Immunocytochemistry, Western Blot; Mouse
Harada, Akina, et al. "Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A." Nuclear medicine and biology 42.2 (2015): 146-154. PMID25451212	Western Blot; Monkey
Mango, Dalila, et al. "Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions." Neuropharmacology 76 (2014): 127-136. PMID23973317	Western Blot; Mouse
Sancesario, Giuseppe, et al. "Levodopa-induced dyskinesias are associated with transient down-regulation of cAMP and cGMP in the caudate-putamen of hemiparkinsonian rats: Reduced synthesis or increased catabolism?." Neurochemistry international 79 (2014): 44-56. PMID25452081	Western Blot; Rat
Nishi, Akinori et al. “Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum.” The Journal of neuroscience?: the official journal of the Society for Neuroscience 28.42 (2008): 10460. PMC2814340	Immunohistochemistry; Mouse
Heine, C., et al. "Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures." Neurosignals 21.3/4 (2013): 197-212. PMID22947663	Immunohistochemistry, Immunofluorescence; Rat
Giorgi, M., et al. "PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in Rat: a key step in parkinsonism physiopathology." Neurobiology of disease 43.1 (2011): 293-303.PMID21515371	Immunohistochemistry; Mouse
Ong, WK et al. “The Role of the PDE4D cAMP Phosphodiesterase in the Regulation of Glucagon-Like Peptide-1 Release.” British Journal of Pharmacology 157.4 (2009): 633–644. PMC2707975	Immunofluorescence, Western Blot; Mouse
Kruse, Lars S., et al. "PDE9A, PDE10A, and PDE11A expression in Rat trigeminovascular pain signalling system." Brain research 1281 (2009): 25-34. PMID19445908	Immunohistochemistry, Immunodepletion, Western Blot; Rat
Dlaboga, Daniel, Hassan Hajjhussein, and James M. O'Donnell. "Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B,-4B, and-10A expression in Rat striatum." Neuropharmacology 54.4 (2008): 745-754. PMID18222493	Western Blot; Rat
Bora, Roop Singh, et al. "Development of a cell‐based assay for screening of phosphodiesterase 10A (PDE10A) inhibitors using a stable recombinant HEK‐293 cell line expressing high levels of PDE10A." Biotechnology and applied biochemistry 49.2 (2008): 129-134. PMID17640173	Immunocytochemistry, Western Blot; Human
Albrecht, Knut, et al. "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the Human vagina: A potential forensic value?." Journal of forensic and legal medicine 14.5 (2007): 270-274. PMID17113813	Immunohistochemistry; Human
Ückert, Stefan, et al. "Immunohistochemical Description of Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Labia Minora." The Journal of Sexual Medicine 4.3 (2007): 602-608.PMID17498099	Immunofluorescence; Human
Ückert, Stefan, et al. "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in Human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." Urology 65.3 (2005): 604-610. PMID15780401	Immunohistochemistry; Human

Publishing research using PD10A-101AP? Please let us know, we can cite the reference in this datasheet.

To view the Specification Sheet for PDE10A Antibody, please click the link below:

PDE10A Antibody | FabGennix

Accessories

Product

Note

Status

Price

PDE10A Antibody FITC

PD10A-FITC

$375.00 *

PDE10A Antibody BIOTIN

PD10A-BIOTIN

$375.00 *

PDE10A Blocking Peptide

P-PD10A

$155.00 *

PDE10A Positive Control

PC-PD10A

$200.00 *

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Selective for PDE10A12 variant

PDE10A12 Antibody

$285.00 *

Selective for PDE10A2 variant

PDE10A2 Antibody

$285.00 *

Select for Phospho-PDE10A

Phospho-PDE10A Antibody

$375.00 *

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Browse these categories as well: Phosphodiesterases, cAMP, Primaries

PDE10A2 Antibody

Product no.: PD10A2-131AP

$285.00

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Description

General Information
Product	PDE10A2 Antibody
Description	Affinity Purified Phosphodiesterase 10A2 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Rat
Immunogen	Synthetic peptide taken within amino acid region 1-50 on human PDE10A2 protein.
Accession #	GenBank: AAD32596.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q9Y233
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Molecular Function	Hydrolase, metal-ion binding, cGMP binding
Subcellular Location	Cytoplasm
Expression	Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Structure	Homodimer
Alternative Nomenclature	5''-cyclic phosphodiesterase 10A antibody cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A antibody cAMP and cAMP-inhibited cGMP 3'' antibody FLJ11894 antibody HSPDE10A antibody Phosphodiesterase 10A antibody

Protein information supplied by UniProt

Accessories

Product

Note

Status

Price

PDE10A2 Antibody FITC

PD10A2-FITC

$375.00 *

PDE10A2 Antibody BIOTIN

PD10A2-BIOTIN

$375.00 *

PDE10A2 Blocking Peptide

P-PD10A2

$155.00 *

PDE10A2 Positive Control

PC-PD10A2

$200.00 *

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Selective for PDE10A12 variant

PDE10A12 Antibody

$285.00 *

Selective for all PDE10A variants

PDE10A Antibody

$320.00 *

Selective for Phospho-PDE10A variants

Phospho-PDE10A Antibody

$375.00 *

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Browse these categories as well: cAMP, Primaries, Phosphodiesterases

PDE10A12 Antibody

Product no.: PD10A12-121AP

$285.00

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Description

General Information
Product	PDE10A12 Antibody Affinity Purified
Description	Affinity Purified Phosphodiesterase 10A12 Antibody
Verified Applications	ELISA, WB
Host	Rabbit
Species Cross Reactivity	Rat
Immunogen	Synthetic peptide taken within amino acid region 50-120 on PDE10A12 protein.
Accession #	GenBank: BAB16383
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.67-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Western Blot	1:500
Protein
Uniprot #	Q9Y233
Molecular Function	Hydrolase, metal-ion binding, cGMP binding
Subcellular Location	Cytoplasm
Expression	Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Structure	Homodimer
Alternative Nomenclature	5''-cyclic phosphodiesterase 10A antibody cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A antibody cAMP and cAMP-inhibited cGMP 3'' antibody FLJ11894 antibody HSPDE 10A antibody PDE 10A antibody Phosphodiesterase 10A antibody Phosphodiesterase 10A12 antibody

Protein information supplied by UniProt

Accessories

Product

Note

Status

Price

PDE10A12 Antibody FITC

PD10A12-FITC

$375.00 *

PDE10A12 Antibody BIOTIN

PD10A12-BIOTIN

$375.00 *

PDE10A12 Blocking Peptide

P-PD10A12

$155.00 *

PDE10A12 Positive Control

PC-PD10A12

$200.00 *

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Selective for all PDE10A variants

PDE10A Antibody

$320.00 *

Selective for PDE10A2 variant

PDE10A2 Antibody

$285.00 *

Selective for Phospho-PDE10A variants

Phospho-PDE10A Antibody

$375.00 *

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Browse these categories as well: cAMP, Phosphodiesterases, Primaries

PDE11A Antibody

Product no.: PD11A-101AP

$320.00

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Description
Publications

General Information
Product	PDE11A Antibody
Description	Affinity Purified Cyclic Nucleotide Phosphodiesterase 11A1 Antibody N-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 100-150 on PDE11A protein, common to all PDE11A variants.
Specificity	This antibody does not cross-react with any of the members of the PDE family. This antibody is common to all PDE11A variants including PDE11A1-PDE11A4.
Accession #	GenBank: CAB82573.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	Q9HCR9
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Molecular Function	Hydrolase, metal-ion binding, cGMP binding
Subcellular Location	Cytoplasm
Expression	Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed i
Alternative Nomenclature	5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody cAMP and cGMP cyclic nucleotide phosphodiesterase 11A antibody Cyclic nucleotide phosphodiesterase 11A1 antibody Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A antibody FLJ23693 antibody MGC133355 antibody MGC133356 antibody PDE 11A antibody pde11 antibody pde11a2 antibody Phosphodiesterase 11A antibody PPNAD2 antibody

Protein information supplied by UniProt

Fabgennix PDE11A Antibody has been used in 14 Publications
P Kelly, Michy. "Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?." Current pharmaceutical design 21.3 (2015): 389-416. PMID25159071	Western Blot; Rat
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the Human ovary." Molecular and cellular endocrinology (2015). PMID25578602	Immunohistochemistry, Immunocompetition; Human
Kelly, Michy P., et al. "Select 3′, 5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain." Cellular signalling 26.2 (2014): 383-397.PMID24184653	Western Blot Immunocompetition; Human, Mouse
Hamilton, Thomas K., et al. "Potential therapeutic applications of phosphodiesterase inhibition in prostate cancer." World journal of urology 31.2 (2013): 325-330.PMID22383129	Western Blot; Human
Ückert, Stefan, et al. "Expression and distribution of phosphodiesterase isoenzymes in the Human seminal vesicles." The journal of sexual medicine 8.11 (2011): 3058-3065. PMID21810184	Immunohistochemistry; Human
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350.PMID21653225	Immunofluorescence, Western Blot; Rat
Ückert, S, et al. "Expression And Distribution Of Key Enzymes Of The Cyclic GMP Signaling In The Human Clitoris: Relation To Phosphodiesterase Type 5 (PDE5)." International Journal Of Impotence Research 23.5 (2011): 206-212. PMID21697861	Immunohistochemistry; Human
Kelly, Michele P. et al. “Phosphodiesterase 11A in Brain Is Enriched in Ventral Hippocampus and Deletion Causes Psychiatric Disease-Related Phenotypes.”Proceedings of the National Academy of Sciences of the United States of America 107.18 (2010): 8457–8462. PMC2889541	Western Blot; Mouse
Kruse, Lars S., et al. "PDE9A, PDE10A, and PDE11A expression in Rat trigeminovascular pain signalling system." Brain research 1281 (2009): 25-34. PMID19445908	Immunohistochemistry, Immunodepletion, Western Blot; Rat
Ückert, Stefan, et al. "Immunohistochemical Description of Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Labia Minora." The Journal of Sexual Medicine 4.3 (2007): 602-608. PMID17498099	Immunofluorescence; Human
Ückert, Stefan, et al. "Immunohistochemical distribution of cAMP-and cGMP-phosphodiesterase (PDE) isoenzymes in the Human prostate." European urology 49.4 (2006): 740-745.PMID16460876	Immunofluorescence, Immunohistochemistry; Human
Loughney, K., J. Taylor, and V. A. Florio. "3′, 5′-cyclic nucleotide phosphodiesterase 11A: localization in Human tissues." International journal of impotence research 17.4 (2005): 320-325. PMID15800651	Immunohistochemistry, Western Blot; Human
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425	Immunofluorescence, Western Blot; Mouse
D'Andrea, Michael R., et al. "Expression of PDE11A in normal and malignant Human tissues." Journal of Histochemistry & Cytochemistry 53.7 (2005): 895-903. PMID15995148	Immunohistochemistry, Western Blot; Human

Publishing research using PD11A-101AP? Please let us know, we can cite the reference in this datasheet.

Accessories

Product

Note

Status

Price

PDE11A Antibody FITC

PD11A-FITC

$375.00 *

PDE11A Antibody BIOTIN

PD11A-BIOTIN

$375.00 *

PDE11A Blocking Peptide

P-PD11A

$155.00 *

PDE11A Positive Control

PC-PD11A

$220.00 *

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C-epitope PDE11A Antibody $320.00 *	C-epitope Phospho-PDE11A Antibody (S117 & S124) $375.00 *	N-epitope Phospho-PDE11A Antibody (S117) $375.00 *
PD11A3-121AP PDE11A3 Antibody $285.00 *	PD11A4-131AP PDE11A4 Antibody $285.00 *	PPD11A-170AP Phospho-PDE11A Antibody (S163) Antibody $375.00 *

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Browse these categories as well: cAMP, Reproduction, Cancer Research, Energy Metabolism, Phosphodiesterases, Primaries

PDE11A Antibody

Product no.: PD11A-112AP

$320.00

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General Information
Product	PDE11A Antibody
Description	Affinity Purified Cyclic Nucleotide Phosphodiesterase 11A1 Antibody C-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 454-468 of human PDE11A.
Specificity	This antibody does not cross-react with any of the members of the PDE family. This antibody is common to all PDE11A variants including PDE11A1-PDE11A4.
Accession #	GenBank: CAB82573.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	C-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:250
Immunofluorescence	1:250
Immunohistochemistry	1:250
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	Q9HCR9
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Molecular Function	Hydrolase, metal-ion binding, cGMP binding
Subcellular Location	Cytoplasm
Expression	Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis.
Alternative Nomenclature	5''-cyclic-AMP and -GMP phosphodiesterase 11A cAMP and cGMP cyclic nucleotide phosphodiesterase 11A Cyclic nucleotide phosphodiesterase 11A1 Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A PDE 11A pde11 pde11a2 Phosphodiesterase 11A PPNAD2

Protein information supplied by UniProt

Fabgennix PDE11A Antibody has been used in 14 Publications
P Kelly, Michy. "Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?." Current pharmaceutical design 21.3 (2015): 389-416. PMID25159071	Western Blot; Rat
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the Human ovary." Molecular and cellular endocrinology (2015). PMID25578602	Immunohistochemistry, Immunocompetition; Human
Kelly, Michy P., et al. "Select 3′, 5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain." Cellular signalling 26.2 (2014): 383-397.PMID24184653	Western Blot Immunocompetition; Human, Mouse
Hamilton, Thomas K., et al. "Potential therapeutic applications of phosphodiesterase inhibition in prostate cancer." World journal of urology 31.2 (2013): 325-330.PMID22383129	Western Blot; Human
Ückert, Stefan, et al. "Expression and distribution of phosphodiesterase isoenzymes in the Human seminal vesicles." The journal of sexual medicine 8.11 (2011): 3058-3065. PMID21810184	Immunohistochemistry; Human
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350.PMID21653225	Immunofluorescence, Western Blot; Rat
Ückert, S, et al. "Expression And Distribution Of Key Enzymes Of The Cyclic GMP Signaling In The Human Clitoris: Relation To Phosphodiesterase Type 5 (PDE5)." International Journal Of Impotence Research 23.5 (2011): 206-212. PMID21697861	Immunohistochemistry; Human
Kelly, Michele P. et al. “Phosphodiesterase 11A in Brain Is Enriched in Ventral Hippocampus and Deletion Causes Psychiatric Disease-Related Phenotypes.”Proceedings of the National Academy of Sciences of the United States of America 107.18 (2010): 8457–8462. PMC2889541	Western Blot; Mouse
Kruse, Lars S., et al. "PDE9A, PDE10A, and PDE11A expression in Rat trigeminovascular pain signalling system." Brain research 1281 (2009): 25-34. PMID19445908	Immunohistochemistry, Immunodepletion, Western Blot; Rat
Ückert, Stefan, et al. "Immunohistochemical Description of Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Labia Minora." The Journal of Sexual Medicine 4.3 (2007): 602-608. PMID17498099	Immunofluorescence; Human
Ückert, Stefan, et al. "Immunohistochemical distribution of cAMP-and cGMP-phosphodiesterase (PDE) isoenzymes in the Human prostate." European urology 49.4 (2006): 740-745.PMID16460876	Immunofluorescence, Immunohistochemistry; Human
Loughney, K., J. Taylor, and V. A. Florio. "3′, 5′-cyclic nucleotide phosphodiesterase 11A: localization in Human tissues." International journal of impotence research 17.4 (2005): 320-325. PMID15800651	Immunohistochemistry, Western Blot; Human
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425	Immunofluorescence, Western Blot; Mouse
D'Andrea, Michael R., et al. "Expression of PDE11A in normal and malignant Human tissues." Journal of Histochemistry & Cytochemistry 53.7 (2005): 895-903. PMID15995148	Immunohistochemistry, Western Blot; Human

Publishing research using PD11A-101AP? Please let us know, we can cite the reference in this datasheet.

To view the specification sheet for PDE11A Antibody, please click the link below:

PDE11A Antibody | FabGennix

Accessories

Product

Note

Status

Price

PDE11A Antibody FITC

PD11A.112-FITC

$375.00 *

PDE11A Antibody BIOTIN

PD11A.112-BIOTIN

$375.00 *

PDE11A Blocking Peptide

P-PD11A.112

$155.00 *

PDE11A Positive Control

PC-PD11A

$220.00 *

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We also recommend

N-epitope PDE11A Antibody $320.00 *	C-epitope Phospho-PDE11A Antibody (S117 & S124) $375.00 *	N-epitope Phospho-PDE11A Antibody (S117) $375.00 *
PD11A3-121AP PDE11A3 Antibody $285.00 *	PD11A4-131AP PDE11A4 Antibody $285.00 *	PPD11A-170AP Phospho-PDE11A Antibody (S163) Antibody $375.00 *

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Browse these categories as well: cAMP, Reproduction, Cancer Research, Energy Metabolism, Phosphodiesterases, Primaries

PDE11A3 Antibody

Product no.: PD11A3-121AP

$285.00

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Description

General Information
Product	PDE11A3 Antibody Affinity Purified
Description	Affinity Purified Phosphodiesterase 11A3 Antibody
Verified Applications	ELISA, IMM, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide unique to PDE11A3 variant
Accession #	GenBank: AB038041.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.68 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	Q9HCR9
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Molecular Function	Hydrolase, metal-ion binding, cGMP binding
Subcellular Location	Cytoplasm
Expression	Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed
Alternative Nomenclature	PDE11A antibody PDE11A3 antibody PPNAD2 antibody

Protein information supplied by UniProt

Accessories

Product

Note

Status

Price

PDE11A3 Antibody FITC

PD11A3-FITC

$375.00 *

PDE11A3 Antibody BIOTIN

PD11A3-BIOTIN

$375.00 *

PDE11A3 Blocking Peptide

P-PD11A3

$155.00 *

PDE11A3 Positive Control

PC-PD11A3

$200.00 *

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Display accessory details

We also recommend

PD11A4-131AP PDE11A4 Antibody $285.00 *	C-epitope Phospho-PDE11A Antibody (S117 & S124) $375.00 *	N-epitope Phospho-PDE11A Antibody (S117) $375.00 *
N-epitope PDE11A Antibody $320.00 *	C-epitope PDE11A Antibody $320.00 *	PPD11A-170AP Phospho-PDE11A Antibody (S163) Antibody $375.00 *

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Browse these categories as well: cAMP, Primaries, Phosphodiesterases

PDE11A4 Antibody

Product no.: PD11A4-131AP

$285.00

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Description

General Information
Product	PDE11A4 Antibody Affinity Purified
Description	Affinity Purified Phosphodiesterase 11A4 Antibody
Verified Applications	ELISA, IMM, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide unique to PDE11A4 variant
Accession #	GenBank: BAB62712.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.70-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:250
Western Blot	1:500
Protein
Uniprot #	Q9HCR9
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Molecular Function	Hydrolase, 3', 5'-cyclic-GMP phosphodiesterase activity, cGMP binding
Subcellular Location	Cytoplasm
Expression	Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed i
Alternative Nomenclature	cGMP phosphodiesterase 11A antibody Pde11a antibody Pde11A2 antibody Pde11A3 antibody PDE11A4 antibody PPNAD2 antibody

Protein information supplied by UniProt

Accessories

Product

Note

Status

Price

PDE11A4 Antibody FITC

PD11A4-FITC

$375.00 *

PDE11A4 Antibody BIOTIN

PD11A4-BIOTIN

$375.00 *

PDE11A4 Blocking Peptide

P-PD11A4

$155.00 *

PDE11A4 Positive Control

PC-PD11A4

$200.00 *

Shipping Options

Bulk and Special Orders Quote

Display accessory details

We also recommend

PD11A3-121AP PDE11A3 Antibody $285.00 *	C-epitope Phospho-PDE11A Antibody (S117 & S124) $375.00 *	N-epitope Phospho-PDE11A Antibody (S117) $375.00 *
N-epitope PDE11A Antibody $320.00 *	C-epitope PDE11A Antibody $320.00 *	PPD11A-170AP Phospho-PDE11A Antibody (S163) Antibody $375.00 *

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Browse these categories as well: cAMP, cGMP, Primaries, Phosphodiesterases

PDE1C Antibody

Product no.: PD1C-301AP

$320.00

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General Information
Product	PDE1C Antibody
Description	Affinity Purified Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) Antibody N-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene. The sequence was taken within amino acid region 1-50.
Specificity	This antibody does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3.
Accession #	GenBank: U40371.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:40-1:100
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:40-1:100
Immunofluorescence	1:100
Immunohistochemistry	1:40-1:100
Immunoprecipitation	1:200
Western Blot	1:500-1:2,000
Protein
Uniprot #	Q14123
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
Molecular Function	Hydrolase, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding
Subcellular Location	Cytosol
Expression	Expressed in several tissues, including brain and heart.
Structure	Homodimer
Alternative Nomenclature	5''-cyclic nucleotide phosphodiesterase 1C Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C Cam PDE 1C HCAM3 HSPDE1C1A Human 3'5' cyclic nucleotide Phosphodiesterase PDE 1C Phosphodiesterase 1C Phosphodiesterase 1C calmodulin dependent

Protein information supplied by UniProt

FabGennix PDE1C Antibody has been used in 16 Publications

Applications: Confocal microscopy, Immunodepletion, Immunofluorescence, Immunohistochemistry, and Western blot

Reactivity: Chicken, Human, Mouse, and Rat

Cesarini, Valeriana, et al. "Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome." Oncotarget (2017).

PMID: 28099939

Applications: Western Blot

Reactivity: Human

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015).

PMID: 25578602

Applications: Immunohistochemistry

Reactivity: Human

Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014).

PMID: 24631654

Applications: Immunohistochemistry, Western Blot

Reactivity: Mouse

Guibinga, Ghiabe-Henri, Fiona Murray, and Nikki Barron. “HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?” Ed. Kjetil Tasken. PLoS ONE 8.5 (2013).

PMCID: 3653951

Applications: Western Blot

Reactivity: Human

Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011).

PMID: 21653225

Applications: Immunofluorescence, Western Blot

Reactivity: Mouse

Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011).

PMID: 20807569

Applications: Western Blot

Reactivity: Human

Abusnina, Abdurazzag, et al. "Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1." Molecular nutrition & food research 55.11 (2011).

PMID: 22045655

Applications: Western Blot

Reactivity: Human

Dong, Hongli, et al. "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." Biochemical pharmacology 79.3 (2010).

PMID: 19737543

Applications: Western Blot

Reactivity: Human

Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, IntegRative and CompaRative Physiology 297.5 (2009).

PMCID: 2777770

Applications: Confocal microscopy, Immunohistochemistry, Immunofluorescence, Western Blot

Reactivity: Mouse

Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009).

PMCID: 2803251

Applications: Western Blot

Reactivity: Rat

Deplano, Stefania, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase during ontogenesis of chick retina." Journal of neuroscience research 86.5 (2008).

PMID: 18041092

Applications: Immunohistochemistry, Western Blot

Reactivity: Chicken

Dunkern, Torsten R., and Armin Hatzelmann. "Characterization Of Inhibitors Of Phosphodiesterase 1C On A Human Cellular System." FEBS Journal 274.18 (2007).

PMID: 17697115

Applications: Western Blot

Reactivity: Human

Murray, Fiona, et al. "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007).

PMID: 16980375

Applications: Western Blot

Reactivity: Human

Santone, Rocco, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase in adult Rat retina." Journal of neuroscience research 84.5 (2006).

PMID: 16881052

Applications: Confocal microscopy, Immunohistochemistry, Western Blot

Reactivity: Rat

Dolci, Susanna, et al. "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases." Biochemical and biophysical research communications 341.3 (2006).

PMID: 16455054

Applications: Immunodepletion, Immunofluorescence, Western Blot

Reactivity: Human

Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005).

PMID: 15856425

Applications: Immunofluorescence, Western Blot

Reactivity: Mouse

Publishing research using PD1C-301AP? Please let us know, we can cite the reference in this datasheet.

On your PDE1c western blot data sheet there are multiple bands from different tissue origin lysates. As we are having problems with the size of PDE1c, can you tell us or mark these sizes of the PDE1C splice variants?

The PDE1C splice variants are described in detail in Yan C et al. The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. J Biol Chem 271:25699-706 (1996). Please refer to this reference as it is useful in describing th